Showing posts with label homocysteine. Show all posts
Showing posts with label homocysteine. Show all posts

Friday, 30 March 2012

New Mums 'Abandoned' During Labour

One in three new mothers is left alone during or just after labour because maternity services are overstretched, according to a survey.

The poll of 3,500 mums found almost half (43%) said they did not have access to a midwife after giving birth.

More than a third (35%) of those questioned by The Royal College of Midwives (RCM) and parenting website Netmums.com said they had been abandoned during or after labour at a time when they felt worried.

Sally Russell, co-founder of Netmums.com, said: "This survey's results should demonstrate to the Government just how stretched maternity services are.

"It shows that our members want, need and deserve one-to-one care from midwives but they are not getting this and are left alone and feeling abandoned during labour, and especially in the vital post-natal period."

    All women can expect individual support from a midwife, supported by a wider maternity team, throughout her labour and birth.

Health Minister Ann Keen

One mother said of her labour: "There were too many people on and off shifts.

"There was no continuity of care, therefore no-one was able to make sound decisions.

"I (had) seven different midwives involved just during labour. I ended up having an emergency Caesarean section."

In 2007, the Government said all women in England should be supported by a midwife they know and trust throughout their pregnancy and after birth.

Ministers promised that "by the end of 2009" women would be able to choose where they give birth and have better continuity of midwifery care.

But the survey found only 68% of women were offered a choice of where to give birth.

Baby buggy

Some mothers felt abandoned

There were some positive responses in the research, including 83% of women saying they had the name and telephone number of a midwife they could contact if they were worried.

And 72% said they had their first appointment with a midwife as soon as they wanted it.

RCM general secretary Cathy Warwick said she was pleased some aspects of maternity services were rated highly but that overall the results painted a "worrying and disturbing picture".

Reacting to the survey, Health Minister Ann Keen said: "There has been record investment in the NHS in recent years including an additional £330m for maternity services.

"All women can expect individual support from a midwife, supported by a wider maternity team, throughout her labour and birth."

Tuesday, 20 March 2012

Overseas students 'to increase in UK universities'

The number of overseas students in UK universities will rise by a further 10% this decade, says a study for the British Council.

Only Australia is set to have a bigger increase in overseas students.

It forecasts that India rather than China will send the most students in this lucrative global market.

Jo Beall, the British Council director of education, says the "next 10 years will be critical" if the UK is to take advantage.

Speaking ahead of the British Council's Going Global conference, Dr Beall says there is a "decade of opportunity" for the UK to benefit from an increasingly-mobile international student population.

Shifting power
"In an increasingly connected and inter-dependent world, a willingness and ability to collaborate internationally and to respond to changing trends are vital," said Dr Beall.

By the end of the last decade there were 3.5m students studying overseas - and even though the rate of increase will slow, the overall number is expected to continue to rise.

Setting out global trends in higher education until 2020, the British Council study forecasts an increasing importance for Asian countries, challenging the longstanding domination of the United States.

By 2020, China will have almost twice as many students as the United States.

But the British Council predicts that it will be India rather than China that will be key player for sending students overseas.

Figures from the Higher Education Statistics Agency show that currently China is by the far the biggest provider of overseas students to the UK -with 67,000 students in the UK, compared with 39,000 from India.

The figures from 2011 show that about 12% of students at UK universities are from overseas - which is categorised as being outside the European Union.

In terms of the potential market for higher education, the British Council highlights that by 2020, just four countries will account for more than half of the world's 18 to 22 year olds - India, China, the United States and Indonesia.

The British Council says that the biggest single expansion in overseas students is likely to be Australia, which it predicts will be teaching an extra 50,000 by 2020.

But it says that the UK could be the second-biggest in terms of increasing overseas student numbers, predicting a rise of 30,000.

The British Council also highlights how university research has become internationalised - with more than a third of research now involving international collaborations.

The forecasts are issued in advance of this week's Going Global conference in London, examining university globalisation, which will bring together 1,300 higher education leaders from around the world.

Friday, 2 March 2012

Genetic Data Nix Folate Role in Heart Disease

The final nail may have been placed in the coffin of homocysteine-lowering therapy as a preventive measure for coronary heart disease.

The overall result from large, unpublished datasets shows lifelong moderate homocysteine elevation has little or no effect on coronary heart disease.

A comprehensive analysis -- including published and unpublished research that involved more than 236,000 participants -- suggests that even lifelong exposure to elevated homocysteine "has little or no effect," according to Robert Clarke, MD, of the Clinical Trial Service Unit at the University of Oxford, in Oxford, England, and colleagues.

The key finding is that, in several large unpublished datasets, genetic variation that increases or decreases natural homocysteine levels did not significantly affect the risk of coronary heart disease, Clarke and colleagues reported online in PLoS Medicine.

That was coupled with a null effect in an updated meta-analysis of 10 clinical trials testing the effect of folic acid, a homocysteine-lowering compound.

Taken together, that evidence suggests that a significant but modest benefit of lower homocysteine in an updated meta-analysis of 86 published case-control studies was an "artifact of publication bias," the researchers argued.

Clarke and colleagues noted that a common genetic variant -- named C677T -- in the methylene tetrahydrofolate reductase gene (MTHFR) markedly affects homocysteine levels.

Specifically, people with the TT genotype (individuals in whom both copies of the MTHFR gene have the nucleotide thymine at position 677) of the C677T polymorphism have natural levels that are about 20% higher than those with the CC variant. The CT variant has an effect that is intermediate but closer to CC than TT.

That suggests the possibility of a natural "Mendelian" experiment, and luckily the increasing use of large scale-genomics analysis has led to the creation of 19 large datasets -- with a total of more than 100,000 participants -- in which variation in the MTHFR gene was analyzed, although not as a primary focus.

Clarke and colleagues designated those studies as "unpublished" because odds ratios for coronary heart disease were not the primary aim and have not been reported. The studies had a total of 48,175 coronary heart disease cases and 67,961 controls.

If the associations seen in the earlier case-control studies were causal, the researchers argued, the 20% higher homocysteine in those with the TT variant should imply about an 8% increase in coronary heart disease risk, compared with CC carriers.

But a meta-analysis of the effect of the TT variant in the 19 studies showed a non-significant odds ratio of 1.02, with a 95% confidence interval from 0.98 to 1.07, they reported.

Even in the sub-population of participants who had not been given folate supplements in food, where the effect of the TT variant might be expected to be stronger, it remained non-significant, with an odds ratio of 1.01.

On the other hand, Clarke and colleagues reported, the updated analysis of the 86 biochemical studies -- with 28,617 cases and 41,857 controls -- suggested that having the TT variant increased the risk of coronary heart disease by 15% (odds ratio 1.15, 95% CI from 1.09 to 1.21).

The results of the two analyses are "discrepant," the researchers noted, and the discrepancy "is too extreme to be plausibly dismissed as a chance finding."

Instead, they argued for a "substantial" effect of publication bias.

To bolster the argument, they noted that their analysis of the 10 intervention studies, with a total of more than 50,000 participants, found that lowering homocysteine for at least five years had no significant effect on the risk of coronary heart disease. The odds ratio was 1.02 (95% CI from 0.96 to 1.08).

"Both the genetic studies and the trials argue against the use of (homocysteine-lowering agents) as a means of reducing coronary heart disease risk," they concluded.